General Information:

Id: 9,687
Diseases: Cardiovascular disease
Homo sapiens
article
Reference: Lautner RQ et al.(2013) Discovery and characterization of alamandine: a novel component of the renin-angiotensin system Circ. Res. 112: 1104-1111 [PMID: 23446738]

Interaction Information:

Comment Using mass spectrometry the authors identified alamandine as a product of the catalytic hydrolysis of the octapeptide Ala1-AngII (angiotensin A) by human ACE2. They demonstrate that alamandine can be formed in the rat heart after Ang-(1–7) perfusion with the use of selected reaction monitoring-mass spectrometry. This indicates that the cardiac tissue contains all necessary components to promote the decarboxylation of the Ang-(1–7) N-terminal aspartate amino acid residue. The sequence of alamandine is very similar to Ang-(1–7), differing only by the presence of an alanine residue in place of an aspartate residue in the amino terminus.
Formal Description
Interaction-ID: 102209

gene/protein

Angiotensin A

increases_quantity of

gene/protein

Alamandine

Comment Using mass spectrometry the authors identified alamandine as a product of the catalytic hydrolysis of the octapeptide Ala1-AngII (angiotensin A) by human ACE2. They demonstrate that alamandine can be formed in the rat heart after Ang-(1–7) perfusion with the use of selected reaction monitoring-mass spectrometry. This indicates that the cardiac tissue contains all necessary components to promote the decarboxylation of the Ang-(1–7) N-terminal aspartate amino acid residue.
Formal Description
Interaction-ID: 102338

gene/protein

ACE2

increases_quantity of

gene/protein

Alamandine

Drugbank entries Show/Hide entries for ACE2
Comment Using mass spectrometry the authors identified alamandine as a product of the catalytic hydrolysis of the octapeptide Ala1-AngII (angiotensin A) by human ACE2. They demonstrate that alamandine can be formed in the rat heart after Ang-(1–7) perfusion with the use of selected reaction monitoring-mass spectrometry. This indicates that the cardiac tissue contains all necessary components to promote the decarboxylation of the Ang-(1–7) N-terminal aspartate amino acid residue.
Formal Description
Interaction-ID: 102339

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin A

Drugbank entries Show/Hide entries for ACE2
Comment Alamandine circulates in human blood; and consistent with previous observations for angiotensin A, the data revealed that nephropathic patients have increased plasmatic concentration of alamandine.
Formal Description
Interaction-ID: 102340

disease

Nephropathy

increases_quantity of

gene/protein

Alamandine

in blood plasma
Comment To further address the role of MrgD in the alamandine effects, binding and functional studies in human MrgD-transfected cells were performed. Fluorescent-labeled alamandine specifically binds to MrgD-stably transfected CHO cells.
Formal Description
Interaction-ID: 102341

gene/protein

Alamandine

interacts (colocalizes) with

gene/protein

MRGPRD