General Information:

Id: 950
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse model
article
Reference: Chauhan NB(2003) Anti-amyloidogenic effect of Allium sativum in Alzheimers transgenic model Tg2576 J Herb Pharmacother 3: 95-107 [PMID: 15277073]

Interaction Information:

Comment Tgs were treated with aged garlic extract (40 mg/kg/d/4 wks). Cerebral levels of sAPPalpha, sAbeta40, sAbeta42 show the following results: increased sAPPalpha by 25% and decreased Abeta40 and Abeta42 by 31% and 32% respectively, compared to untreated Tgs.
Formal Description
Interaction-ID: 5794

environment

Allium sativum (garlic) supplementation

increases_quantity of

gene/protein

sAPP-alpha

Comment Tgs were treated with aged garlic extract (40 mg/kg/d/4 wks). Cerebral levels of sAPPalpha, sAbeta40, sAbeta42 show the following results: increased sAPPalpha by 25% and decreased Abeta40 and Abeta42 by 31% and 32% respectively, compared to untreated Tgs.
Formal Description
Interaction-ID: 5797

environment

Allium sativum (garlic) supplementation

decreases_quantity of

Comment Tgs were treated with aged garlic extract (40 mg/kg/d/4 wks). Cerebral levels of sAPPalpha, sAbeta40, sAbeta42 show the following results: increased sAPPalpha by 25% and decreased Abeta40 and Abeta42 by 31% and 32% respectively, compared to untreated Tgs.
Formal Description
Interaction-ID: 5841

environment

Allium sativum (garlic) supplementation

decreases_quantity of