General Information:

Id: 941
Diseases: Neurological
Parkinson disease
Mus musculus
BTO:0000233 cerebral cortex
article
Reference: Lee HS et al.(2010) Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. Stem Cells 28: 501-512 [PMID: 20049900]

Interaction Information:

Comment Foxa2 and Nurr1 cooperatively induce TH Expression in non-dopaminergic precursors derived from mouse fetal cortices.
Formal Description
Interaction-ID: 5695

gene/protein

NR4A2

increases_activity of

Comment Foxa2 and Nurr1 cooperatively induce TH Expression in non-dopaminergic precursors derived from mouse fetal cortices.
Formal Description
Interaction-ID: 5698

gene/protein

FOXA2

increases_activity of

gene/protein

NR4A2

Comment Foxa2 inhibits cell proliferation.
Formal Description
Interaction-ID: 5702

gene/protein

FOXA2

decreases_activity of

Comment Foxa2 induces cell cycle arrest by inhibiting the G1 to S transition of the cell cycle.
Formal Description
Interaction-ID: 5704

gene/protein

FOXA2

increases_activity of

by inhibiting the G1 to S transition
Comment Foxa2 induces cell cycle arrest by inhibiting the G1 to S transition of the cell cycle.
Formal Description
Interaction-ID: 5707

gene/protein

FOXA2

decreases_activity of

Comment Foxa2 overexpression upregulated the mRNA levels of Ngn2, Mash1, and NeuroD in cortical NPCs.
Formal Description
Interaction-ID: 5708

gene/protein

FOXA2

increases_expression of

gene/protein

NEUROG2

Comment Foxa2 overexpression upregulated the mRNA levels of Ngn2, Mash1, and NeuroD in cortical NPCs.
Formal Description
Interaction-ID: 5709

gene/protein

FOXA2

increases_expression of

gene/protein

NEUROD1

Comment Foxa2 overexpression upregulated the mRNA levels of Ngn2, Mash1, and NeuroD in cortical NPCs.
Formal Description
Interaction-ID: 5710

gene/protein

FOXA2

increases_expression of

gene/protein

ASCL1