General Information:

Id: 792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Koren J 3rd et al.(2009) Chaperone signalling complexes in Alzheimers disease J. Cell. Mol. Med. 13: 619-630 [PMID: 19449461]

Interaction Information:

Comment Overexpression of PSEN1 and APP mutant genes in transgenic mice showed that they enhance production of a 42-amino acid N-terminal peptide from APP, which enters the extracellular milieu (amyloidosis).
Formal Description
Interaction-ID: 4546

gene/protein mutant

APP-mut

increases_processing of

in extracellular milieu; if APP-mut is overexpressed