General Information:

Id: 750 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
Mammalia
BTO:0003704 H4 neuroglioma cell
article
Reference: Yoon EJ et al.(2009) Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis Exp. Mol. Med. 41: 611-617 [PMID: 19478559]

Interaction Information:

Comment Both SOD1 wt and the SOD1 G93A mutant interact with intracellular amyloid beta protein (amyloid-beta(42) peptide. The interaction between amyloid beta protein and the SOD1 G93A mutant was approximately five times greater than that between amyloid beta protein and wild-type SOD1. As expected, amyloid beta protein also bound to endogenous SOD1.
Formal Description
Interaction-ID: 4225

gene/protein

SOD1

interacts (colocalizes) with

Drugbank entries Show/Hide entries for SOD1
Comment Both SOD1 wt and the SOD1 G93A mutant interact with intracellular amyloid beta protein (amyloid-beta(42) peptide. The interaction between amyloid beta protein and the SOD1 G93A mutant was approximately five times greater than that between amyloid beta protein and wild-type SOD1. As expected, amyloid beta protein also bound to endogenous SOD1.
Formal Description
Interaction-ID: 4227

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

Comment Amyloid beta protein (amyloid-beta(42) peptide) reduces the enzymatic activity of the endogenous SOD1 and of transfected wild-type SOD1-FLAG proteins. The SOD1 activity of the SOD1G93A mutant, analyzed as a functional enzyme, was greatly reduced by Amyloid beta protein (amyloid-beta(42) peptide) compared to wild-type SOD1.
Formal Description
Interaction-ID: 4240

decreases_activity of

gene/protein

SOD1

Drugbank entries Show/Hide entries for SOD1
Comment Amyloid beta protein (amyloid-beta(42) peptide) reduces the enzymatic activity of the endogenous SOD1 and of transfected wild-type SOD1-FLAG proteins. The SOD1 activity of the SOD1G93A mutant, analyzed as a functional enzyme, was greatly reduced by Amyloid beta protein (amyloid-beta(42) peptide) compared to wild-type SOD1.
Formal Description
Interaction-ID: 4242

decreases_activity of

gene/protein mutant

SOD1-p.G93A