General Information:

Id: 750 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
BTO:0003704 H4 neuroglioma cell
Reference: Yoon EJ et al.(2009) Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis Exp. Mol. Med. 41: 611-617 [PMID: 19478559]

Interaction Information:

Comment Amyloid beta protein (amyloid-beta(42) peptide) reduces the enzymatic activity of the endogenous SOD1 and of transfected wild-type SOD1-FLAG proteins. The SOD1 activity of the SOD1G93A mutant, analyzed as a functional enzyme, was greatly reduced by Amyloid beta protein (amyloid-beta(42) peptide) compared to wild-type SOD1.
Formal Description
Interaction-ID: 4240

decreases_activity of



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