General Information:

Id: 7,284
Diseases: Atherosclerosis
Rattus norvegicus
aortic A10 vascular smooth muscle cell
article/cited
Reference: Li J et al.(2013) c-Ski inhibits the proliferation of vascular smooth muscle cells via suppressing Smad3 signaling but stimulating p38 pathway Cell. Signal. 25: 159-167 [PMID: 22986000]

Interaction Information:

Comment TGF-beta signaling stimulates vascular smooth muscle cell proliferation which plays a role in the development of intimal hyperplasia, a hallmark of atherosclerosis. (cited information)
Formal Description
Interaction-ID: 71518
Comment TGF-beta signaling stimulates vascular smooth muscle cell proliferation which plays a role in the development of intimal hyperplasia, a hallmark of atherosclerosis. (cited information)
Formal Description
Interaction-ID: 71519
Comment TGF-beta signaling stimulates vascular smooth muscle cell proliferation which plays a role in the development of intimal hyperplasia, a hallmark of atherosclerosis. (cited information)
Formal Description
Interaction-ID: 71520

increases_activity of

Comment Overexpression of Ski suppresses TGF-beta-induced Smad3 phosphorylation but activates p38 to upregulate p21 and p27.
Formal Description
Interaction-ID: 71521

gene/protein

SKI

decreases_activity of

gene/protein

SMAD3

via dephosphorylation
Comment Overexpression of Ski suppresses TGF-beta-induced Smad3 phosphorylation but activates p38 to upregulate p21 and p27.
Formal Description
Interaction-ID: 71522

gene/protein

SKI

increases_activity of

gene/protein

MAPK14

Drugbank entries Show/Hide entries for MAPK14
Comment Overexpression of Ski inhibits TGF-beta- induced A10 cell proliferation. Vascular injury induces arterial vascular smooth muscle cell proliferation. During this process endogenous SKI protein expression decreased in a time-dependent manner.
Formal Description
Interaction-ID: 71523

gene/protein

SKI

decreases_activity of

via inhibition of TGFbeta signaling but stimulating p38 pathway