General Information:

Id: 7,224
Diseases: Myocardial infarction - [OMIM]
Rattus norvegicus
article/cited
Reference: [PMID: 24155330]

Interaction Information:

Comment Canonical TGF-beta signaling induces the differentiation of fibroblasts into myofibroblasts. This process is called fibroblast-to-myofibroblast phenoconversion and is induced by cardiac stress and injury. (cited information)
Formal Description
Interaction-ID: 71092

increases_activity of

in cardiac myofibroblasts; induced by cardiac stress
Comment Expression of Meox1 and Meox2 is downregulated during fibroblast to myoblast phenoconversion.
Formal Description
Interaction-ID: 71094

decreases_expression of

gene/protein

MEOX1

in cardiac myofibroblasts
Comment Expression of Meox1 and Meox2 is downregulated during fibroblast to myoblast phenoconversion.
Formal Description
Interaction-ID: 71100

decreases_expression of

gene/protein

MEOX2

in cardiac myofibroblasts
Comment Overexpression of Meox2 induces myofibroblast proliferation, although Meox2 overexpression induces cell cycle arrest in vascular endothelial cells. This indicates that the Meox2-mediated effect on cell proliferation is dependent on the cell type.
Formal Description
Interaction-ID: 71102

gene/protein

MEOX2

increases_activity of

of cardiac myofibroblasts
Comment Overexpression of Ski diminishes, but does not fully reverse, the myofibroblast phenotype.
Formal Description
Interaction-ID: 71103

gene/protein

SKI

decreases_activity of

in cardiac myofibroblasts
Comment Ski overexpression resulted in a 5.5-fold increase in Meox2 mRNA expression levels over controls, but had no effect on levels of Meox1.
Formal Description
Interaction-ID: 71104

gene/protein

SKI

increases_expression of

gene/protein

MEOX2

in cardiac myofibroblasts
Comment TGF-beta1 stimulation increases Meox2 level, but has no effect on Meox1.
Formal Description
Interaction-ID: 71105

increases_expression of

gene/protein

MEOX2

in cardiac myofibroblasts
Comment Zeb2 is a repressor of Meox2 transcription in human umbilical vein endothelial cells. (cited information)
Formal Description
Interaction-ID: 71106

gene/protein

ZEB2

decreases_expression of

gene/protein

MEOX2

in human umbilical vein endothelial cells
Comment Zeb2 expression is upregulated during fibroblast-to-myofibroblast differentiation.
Formal Description
Interaction-ID: 71108

gene/protein

ZEB2

increases_activity of

in cardiac myofibroblasts
Comment Overexpression of Ski reduces Zeb2 expression.
Formal Description
Interaction-ID: 71109

gene/protein

SKI

decreases_expression of

gene/protein

ZEB2

in cardiac myofibroblasts
Comment Meox2 levels decrease whereas Zeb2 increases in the cytoplasm following myocardial infarction.
Formal Description
Interaction-ID: 71114

decreases_quantity of

gene/protein

MEOX2

in MI-induced adult rats
Comment Meox2 levels decrease whereas Zeb2 increases in the cytoplasm following myocardial infarction.
Formal Description
Interaction-ID: 71116

increases_quantity of

gene/protein

ZEB2

in MI-induced adult rats
Comment Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion. (cited information)
Formal Description
Interaction-ID: 71127

increases_activity of

Comment Overexpression of Meox2 diminishes the myofibroblast phenotype.
Formal Description
Interaction-ID: 71128

gene/protein

MEOX2

decreases_activity of

in cardiac myofibroblasts