General Information:

Id: 7,173 (click here to show other Interactions for entry)
Diseases: Cancer
Ciliopathy
Nephronophthisis
Mammalia
review
Reference: [PMID: 26045258]

Interaction Information:

Comment Integrin-linked kinase, an integrin-associated actin and tubulin cytoskeleton-interacting effector that mediates TGFbeta signaling, was found to be a negative regulator of the Hippo kinase cascade in cancer cells by inhibiting MYPT1, which leads to inhibition of NF2 and nuclear accumulation of YAP/TAZ.
Formal Description
Interaction-ID: 70721

gene/protein

ILK

decreases_activity of

gene/protein

PPP1R12A

in cancer cells