General Information:

Id: 6,845
Diseases: Inflammatory bowel disease
Homo sapiens
896 CD cases and 3204 healthy controls all of Caucasian origin
article
Reference: McGovern DP et al.(2010) Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohns disease Hum. Mol. Genet. 19: 3468-3476 [PMID: 20570966]

Interaction Information:

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66610

gene/protein

ARPC1A

affects_activity of

disease

Inflammatory bowel disease

Comment FUT2 rs602662 and FUT2-p.W143X are both associated with Crohn disease.
Formal Description
Interaction-ID: 66611

increases_activity of

disease

Inflammatory bowel disease

Comment Patients with FUT2-p.W143X allele do not express ABO antigens in saliva.
Formal Description
Interaction-ID: 66612

gene/protein mutant

FUT2-p.W143X

increases_activity of

disease

Inflammatory bowel disease

Comment Patients with FUT2-p.W143X allele do not express ABO antigens in saliva.
Formal Description
Interaction-ID: 66613

gene/protein mutant

FUT2-p.W143X

NOT increases_activity of

gene/protein

ABO

in saliva
Drugbank entries Show/Hide entries for ABO
Comment Patients with FUT2-p.W143X allele do not express ABO antigens in saliva.
Formal Description
Interaction-ID: 66614

gene/protein

FUT2

increases_activity of

gene/protein

ABO

in saliva
Drugbank entries Show/Hide entries for ABO
Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66615

gene/protein

ARPC1A

increases_activity of

cellular component

cell junction

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66616

gene/protein

EXOC2

affects_activity of

disease

Inflammatory bowel disease

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66617

gene/protein

ARPC1A

increases_activity of

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66618

gene/protein

CADM1

affects_activity of

disease

Inflammatory bowel disease

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66619

gene/protein

MMD2

affects_activity of

disease

Inflammatory bowel disease

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66620

gene/protein

MMD2

increases_activity of

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66621

gene/protein

TAB1

affects_activity of

disease

Inflammatory bowel disease

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 66622

gene/protein

TAB1

increases_activity of

Comment GWAS in 896 Crohn disease cases and 3204 healthy controls identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology (CADM1), macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 , a gene involved in the gastrointestinal mucosal expression of blood group A and B antigens.
Formal Description
Interaction-ID: 67910

gene/protein

EXOC2

affects_activity of