General Information:

Id: 6,785
Diseases: Cancer
Homo sapiens
BTO:0000552 HaCaT cell
article/cited
Reference: Frederick JP et al.(2004) Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element Mol. Cell. Biol. 24: 2546-2559 [PMID: 14993291]

Interaction Information:

Comment Smad3 is involved not only in the TGF-beta-mediated transcriptional activation of PAI-1 but also the TGF-beta-induced repression of c-myc.
Formal Description
Interaction-ID: 65883

gene/protein

SMAD3

increases_expression of

gene/protein

SERPINE1

as shown in BALB/MK cells or primary keratinocytes derived from wild-type and Smad3 (ex1/ex1) homozygous null littermates
Drugbank entries Show/Hide entries for SERPINE1
Comment Smad3 is involved not only in the TGF-beta-mediated transcriptional activation of PAI-1 but also the TGF-beta-induced repression of c-myc.
Formal Description
Interaction-ID: 65884

gene/protein

SMAD3

decreases_expression of

gene/protein

MYC

as shown in BALB/MK cells or primary keratinocytes derived from wild-type and Smad3 (ex1/ex1) homozygous null littermates
Comment The Smads play an essential role in TGF-beta-mediated repression of c-myc. TGF-beta induces the recruitment of Smad3 and Smad4 to an element within the c-myc promoter similar to the previously identified stromelysin TIE (TGF-beta inhibitory element) through a direct interaction with the MH1 (N-terminal Mad homology domain 1) domain of Smad3.
Formal Description
Interaction-ID: 65886

gene/protein

TGFB1

increases_activity of

gene/protein

SMAD3

Drugbank entries Show/Hide entries for TGFB1
Comment TGF-beta initiates its signal through binding the TGF-beta type II serine/threonine (Ser/Thr) receptor kinase, which in turn phosphorylates the type I Ser/Thr receptor, forming an activated receptor complex. The activated type I receptor is then able to phosphorylate its intracellular effector substrates, which include the highly homologous receptor Smads, Smad2 and Smad3 (cited information).
Formal Description
Interaction-ID: 65896

increases_activity of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment TGF-beta initiates its signal through binding the TGF-beta type II serine/threonine (Ser/Thr) receptor kinase, which in turn phosphorylates the type I Ser/Thr receptor, forming an activated receptor complex. The activated type I receptor is then able to phosphorylate its intracellular effector substrates, which include the highly homologous receptor Smads, Smad2 and Smad3 (cited information).
Formal Description
Interaction-ID: 65898

increases_activity of

gene/protein

SMAD3