General Information:

Id: 6,764
Diseases: Metabolic
Homo sapiens
endothelial cell
article
Reference: Chen PY et al.(2014) Fibroblast growth factor receptor 1 is a key inhibitor of TGFbeta signaling in the endothelium Sci Signal 7: RA90 [PMID: 25249657]

Interaction Information:

Comment FGFR1 is the most abundant FGFR-encoding mRNA expressed in human endothelial cells, such as HUVECs, HUAECs, HDLECs.
Formal Description
Interaction-ID: 65738

gene/protein

FGFR1

is_expressed_in

tissue/cell line

endothelial cell

Drugbank entries Show/Hide entries for FGFR1
Comment Knockdown of FGFR1 is sufficient to increase TGFbeta signaling and induces EndMT.
Formal Description
Interaction-ID: 65740

gene/protein

FGFR1

decreases_activity of

in HUVECs
Drugbank entries Show/Hide entries for FGFR1
Comment Knockdown of FGFR1 is sufficient to increase TGFbeta signaling and induces EndMT.
Formal Description
Interaction-ID: 65741

gene/protein

FGFR1

decreases_activity of

process

endothelial to mesenchymal transition

in HUVECs
Drugbank entries Show/Hide entries for FGFR1
Comment Knockdown of FGFR1, but not of FGFR3 or FGFR4, increases the expression of TGFbeta1, TGFbeta2, and TGFbetaR1, leading to activation of TGFbeta signaling as demonstrated by increased phosphorylation of Smad2.
Formal Description
Interaction-ID: 65742

gene/protein

FGFR1

decreases_expression of

gene/protein

TGFB1

in HUVECs
Drugbank entries Show/Hide entries for FGFR1 or TGFB1
Comment Knockdown of FGFR1, but not of FGFR3 or FGFR4, increases the expression of TGFbeta1, TGFbeta2, and TGFbetaR1, leading to activation of TGFbeta signaling as demonstrated by increased phosphorylation of Smad2.
Formal Description
Interaction-ID: 65746

gene/protein

FGFR1

decreases_expression of

gene/protein

TGFB2

in HUVECs
Drugbank entries Show/Hide entries for FGFR1
Comment Knockdown of FGFR1, but not of FGFR3 or FGFR4, increases the expression of TGFbeta1, TGFbeta2, and TGFbetaR1, leading to activation of TGFbeta signaling as demonstrated by increased phosphorylation of Smad2.
Formal Description
Interaction-ID: 65747

gene/protein

FGFR1

decreases_expression of

gene/protein

TGFBR2

in HUVECs
Drugbank entries Show/Hide entries for FGFR1 or TGFBR2