General Information:

Id: 6,756
Diseases: Metabolic
Mammalia
article
Reference: Colland F et al.(2004) Functional proteomics mapping of a human signaling pathway Genome Res. 14: 1324-1332 [PMID: 15231748]

Interaction Information:

Comment By combining a large-scale yeast two-hybrid-based protein-protein interaction mapping with a systematic functional validation in mammalian cells interaction of SMAD1 with ZNF76 has been identified.
Formal Description
Interaction-ID: 65704

gene/protein

SMAD1

interacts (colocalizes) with

gene/protein

ZNF76

Comment TGFbeta signaling as well as BMP signaling phosphorylates and activates SMAD proteins which then regulate target gene expression in collaboration with other transcriptional partners. (cited information)
Formal Description
Interaction-ID: 65706

gene/protein

SMAD1

increases_activity of

Comment TGFbeta signaling as well as BMP signaling phosphorylates and activates SMAD proteins which then regulate target gene expression in collaboration with other transcriptional partners. (cited information)
Formal Description
Interaction-ID: 65708
Comment SMAD3 and SMAD1 are players of the SMAD signaling. (cited information)
Formal Description
Interaction-ID: 65802

gene/protein

SMAD3

increases_activity of

Comment SMAD3 and SMAD1 are players of the SMAD signaling. (cited information)
Formal Description
Interaction-ID: 65938

gene/protein

SMAD2

increases_activity of

Drugbank entries Show/Hide entries for SMAD2