General Information:

Id: 6,731
Diseases: Cancer
Lung cancer - [OMIM]
Homo sapiens
article
Reference: Wu YY et al.(2011) SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer Oncogene 30: 3682-3693 [PMID: 21441952]

Interaction Information:

Comment Lentivirus-transduced stable knockdown of SCUBE3 by siRNA suppresses cancer cell migration and invasion.
Formal Description
Interaction-ID: 65136

gene/protein

SCUBE3

increases_activity of

process

cell migration

in lung adenocarcinoma cell line CL1-5
Comment The CUB domain of SCUBE3 interacted with the with the extracellular region of TGFbetaR-II and vice versa.
Formal Description
Interaction-ID: 65138

gene/protein

SCUBE3

interacts (colocalizes) with

gene/protein

TGFBR2

Drugbank entries Show/Hide entries for TGFBR2
Comment The CUB domain of SCUBE3 interacted with the with the extracellular region of TGFbetaR-II and vice versa.
Formal Description
Interaction-ID: 65139

gene/protein

TGFBR2

interacts (colocalizes) with

gene/protein

SCUBE3

Drugbank entries Show/Hide entries for TGFBR2
Comment SCUBE3 induces SMAD2 phosphorylation indicating that SCUBE3 is able to induce the TGF-beta receptor signaling.
Formal Description
Interaction-ID: 65142

gene/protein

SCUBE3

increases_phosphorylation of

gene/protein

SMAD2

in lung cancer cells H1299
Drugbank entries Show/Hide entries for SMAD2
Comment SCUBE3 induces SMAD2 phosphorylation indicating that SCUBE3 is able to induce the TGF-beta receptor signaling.
Formal Description
Interaction-ID: 65144

gene/protein

SCUBE3

increases_activity of

in lung cancer cells H1299
Comment TGF-beta receptor signaling pathway leads to phosphorylation of SMAD2. (cited information)
Formal Description
Interaction-ID: 65146

increases_phosphorylation of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug, MMP-2, PAI-1, TGF-beta1, VEGF, Snail and MMP-9.
Formal Description
Interaction-ID: 65149

gene/protein

SCUBE3

increases_expression of

gene/protein

SNAI2

in lung cancer cells H1299
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1, TGF-beta1, VEGF, Snail and MMP-9.
Formal Description
Interaction-ID: 65152

gene/protein

SCUBE3

increases_expression of

gene/protein

MMP2

in lung cancer cells H1299
Drugbank entries Show/Hide entries for MMP2
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1 (SERPINE1), TGF-beta1, VEGF, Snail and MMP-9. SCUBE3 is a well known ligand of TGFbeta receptor.
Formal Description
Interaction-ID: 65154

gene/protein

SCUBE3

increases_expression of

gene/protein

SERPINE1

in lung cancer cells H1299; via activation of TGFbeta signaling
Drugbank entries Show/Hide entries for SERPINE1
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1 (SERPINE1), TGF-beta1, VEGF, Snail and MMP-9.
Formal Description
Interaction-ID: 65156

gene/protein

SCUBE3

increases_expression of

gene/protein

TGFB1

in lung cancer cells H1299
Drugbank entries Show/Hide entries for TGFB1
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1 (SERPINE1), TGF-beta1, VEGF, Snail and MMP-9.
Formal Description
Interaction-ID: 65159

gene/protein

SCUBE3

increases_expression of

gene/protein

VEGFA

in lung cancer cells H1299
Drugbank entries Show/Hide entries for VEGFA
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1 (SERPINE1), TGF-beta1, VEGF, Snail (SNAI1) and MMP-9.
Formal Description
Interaction-ID: 65160

gene/protein

SCUBE3

increases_expression of

gene/protein

SNAI1

in lung cancer cells H1299
Comment SCUBE3 treatment in H1299 cell increased the expression of most of the Smad2/3 target genes, including Slug (SNAI2), MMP-2, PAI-1 (SERPINE1), TGF-beta1, VEGF, Snail (SNAI1) and MMP-9.
Formal Description
Interaction-ID: 65162

gene/protein

SCUBE3

increases_expression of

gene/protein

MMP9

in lung cancer cells H1299
Comment SCUBE3 triggers epithelial-mesenchymal transition by activating TGF-beta signaling.
Formal Description
Interaction-ID: 65167

gene/protein

SCUBE3

increases_activity of

in lung cancer cells H1299 and A549
Comment The CUB domain of SCUBE3 interacted with the with the extracellular region of TGFbetaR-II indicating that SCUBE3 is a ligand of TGFbetaR-II and is therefore involved in TGF-beta signaling.
Formal Description
Interaction-ID: 65173

gene/protein

TGFBR2

increases_activity of

Drugbank entries Show/Hide entries for TGFBR2