General Information:

Id: 658 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Gotz J et al.(2008) An update on the toxicity of Abeta in Alzheimers disease. Neuropsychiatr Dis Treat 4: 1033-1042 [PMID: 19337449]

Interaction Information:

Comment The major proteinaceous component of the amyloid plaques is a 40- to 42-amino acid polypeptide termed Abeta (Abeta40 and Abeta42), which is derived by proteolytic cleavage from the amyloid precursor protein, APP, as part of normal cellular metabolism. Abeta42 is the more fibrillogenic and neurotoxic species. Recent evidence suggests that Abeta40 may prevent Abeta42 from aggregating and forming plaques.
Formal Description
Interaction-ID: 3512

increases_quantity of