General Information:

Id: 658 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Gotz J et al.(2008) An update on the toxicity of Abeta in Alzheimers disease. Neuropsychiatr Dis Treat 4: 1033-1042 [PMID: 19337449]

Interaction Information:

Comment The major proteinaceous component of the amyloid plaques is a 40- to 42-amino acid polypeptide termed Abeta (Abeta40 and Abeta42), which is derived by proteolytic cleavage from the amyloid precursor protein, APP, as part of normal cellular metabolism. Abeta42 is the more fibrillogenic and neurotoxic species. Recent evidence suggests that Abeta40 may prevent Abeta42 from aggregating and forming plaques.
Formal Description
Interaction-ID: 3512

increases_quantity of

Comment Aging specifically increased the sensitivity of mitochondria to oligomeric Abeta42 damage indicating that while oligomeric and fibrillar Abeta42 are both toxic, they exert different degrees of toxicity in mitochondria from older animals.
Formal Description
Interaction-ID: 3528

decreases_activity of

cellular component

mitochondrion

Comment Abeta42 is the more fibrillogenic and neurotoxic species. Recent evidence suggests that Abeta40 may prevent Abeta42 from aggregating and forming plaques.
Formal Description
Interaction-ID: 80152

increases_quantity of

complex/PPI

Amyloid beta peptide (fibrillar)