General Information:

Id: 6,483
Diseases: Lung disease
Homo sapiens
article/cited
Reference: Dennler S et al.(1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene EMBO J. 17: 3091-3100 [PMID: 9606191]

Interaction Information:

Comment TGFbeta induces the expression of human plasminogen activator inhibitor 1 (SERPINE1, PAI-1). TGF-beta activates SMAD3/4 complexes which bind to specific sites (CAGA boxes) within the promoter of the human PAI-1 gene.
Formal Description
Interaction-ID: 61516

gene/protein

TGFB1

increases_expression of

gene/protein

SERPINE1

Drugbank entries Show/Hide entries for TGFB1 or SERPINE1
Comment TGFbeta signaling results in SMAD2 and SMAD3 phosphorylation. SMAD2/3 form heteromeric complexes with SMAD4 and these complexes are translocated to the nucleus to induce the expression of target genes. (cited information)
Formal Description
Interaction-ID: 61517

increases_activity of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment TGFbeta signaling results in SMAD2 and SMAD3 phosphorylation. SMAD2/3 form heteromeric complexes with SMAD4 and these complexes are translocated to the nucleus to induce the expression of target genes. (cited information)
Formal Description
Interaction-ID: 61518

increases_activity of

gene/protein

SMAD3

Comment TGFbeta signaling results in SMAD2 and SMAD3 phosphorylation. SMAD2/3 form heteromeric complexes with SMAD4 and these complexes are translocated to the nucleus to induce the expression of target genes. (cited information)
Formal Description
Interaction-ID: 61519

gene/protein

SMAD2

interacts (colocalizes) with

gene/protein

SMAD4

The heteromeric complex binds to CAGA boxes, within the promoter of target genes and initiates transcription
Drugbank entries Show/Hide entries for SMAD2
Comment TGFbeta signaling results in SMAD2 and SMAD3 phosphorylation. SMAD2/3 form heteromeric complexes with SMAD4 and these complexes are translocated to the nucleus to induce the expression of target genes. (cited information)
Formal Description
Interaction-ID: 61520

gene/protein

SMAD3

interacts (colocalizes) with

gene/protein

SMAD4

The heteromeric complex binds to CAGA boxes, within the promoter of target genes and initiates transcription
Comment Overexpression of Smad7 leads to a 50% inhibition of TGFbeta-induced transcription of the CAGA box reporter construct. (CAGA boxes are the binding sites for SMAD3/4 complexes on target genes)
Formal Description
Interaction-ID: 61521

gene/protein

SMAD7

decreases_activity of

in HepG2 cells