General Information:

Id: 6,482
Diseases: Lung disease
Pulmonary fibrosis, idiopathic - [OMIM]
Homo sapiens
article
Reference: Newman DR et al.Expression of WNT5A in Idiopathic Pulmonary Fibrosis and its Control by TGF-beta and WNT7B in Human Lung Fibroblasts [PMID: 26538547]

Interaction Information:

Comment In IPF patients, Wnt5A reactivity was more widely observed than in control subjects. Wnt5A is strongly expressed in airway and alveolar epithelium, endothelial cells, smooth muscle of airways and vessels of all sizes, and almost all interstitial fibroblasts.
Formal Description
Interaction-ID: 61511

increases_quantity of

gene/protein

WNT5A

in lung tissue from IPF or UIP patients
Comment Addition of TGFbeta increases the amount of WNT5A, a regulator of the canonical Wnt-signaling pathway, in fibroblasts.
Formal Description
Interaction-ID: 61512

gene/protein

TGFB1

increases_quantity of

gene/protein

WNT5A

in fibroblasts
Drugbank entries Show/Hide entries for TGFB1
Comment Overexpression of adenoviral transduced Wnt7B with/without TGF-beta1 treatment significantly increased Wnt5A protein expression in normal human smooth muscle cells and fibroblasts but not in IPF myofibroblasts.
Formal Description
Interaction-ID: 61513

gene/protein

WNT7B

increases_quantity of

gene/protein

WNT5A

in normal human smooth muscle cells and fibroblasts but not in IPF myofibroblasts where Wnt5A was already highly expressed
Comment WNT5A activates or inhibits canonical Wnt-signaling pathway, depending on the receptor context. (cited information)
Formal Description
Interaction-ID: 61514

gene/protein

WNT5A

affects_activity of

in fibroblasts
Comment TGFbeta1 is a cytokine acting in the TGFbeta signaling pathway. (cited information)
Formal Description
Interaction-ID: 61515

gene/protein

TGFB1

increases_activity of

Drugbank entries Show/Hide entries for TGFB1