General Information:

Id: 6,160
Diseases: Metabolic
Mus musculus
Fbln2-/-
article
Reference: Zhang H et al.(2014) Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-beta signalling Clin. Sci. 126: 275-288 [PMID: 23841699]

Interaction Information:

Comment After subcutaneous infusion of AngII in fibulin-2 null and WT mice, WT mice developed significant cardiac hypertrophy, whereas the Fbln2-/- showed no response.
Formal Description
Interaction-ID: 57618

gene/protein

FBLN2

affects_activity of

Comment Fibulin-2 is essential for AngII-induced TGF-beta-mediated cardiac hypertrophy via enhanced TGF-beta activation.
Formal Description
Interaction-ID: 57619

gene/protein

FBLN2

increases_activity of

gene/protein

TGFB1

Drugbank entries Show/Hide entries for TGFB1
Comment Fibulin-2 is essential for AngII-induced TGF-beta-mediated cardiac hypertrophy via enhanced TGF-beta activation.
Formal Description
Interaction-ID: 61035

gene/protein

FBLN2

increases_activity of