General Information:

Id: 613 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Chen Y et al.(2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimers amyloid peptides via up-regulating BACE1 transcription Proc Natl Acad Sci U S A 106: 3907-3912 [PMID: 19237574]

Interaction Information:

Comment In N2a neuroblastoma cells stably expressing human APP (N2a695) metformin treatment increased the levels of both intracellular and extracellular A-beta-40/42 in a dose-dependent manner, similar effects were seen in primary cortical neurons.
Formal Description
Interaction-ID: 3253

drug/chemical compound

Metformin

increases_quantity of

in a dose-dependent manner
Drugbank entries Show/Hide entries for Metformin