General Information:

Id: 6,076
Diseases: Metabolic
Mammalia
article
Reference: Tang WB et al.(2010) Smad anchor for receptor activation (SARA) in TGF-beta signaling Front Biosci (Elite Ed) 2: 857-860 [PMID: 20515759]

Interaction Information:

Comment ZFYVE9 (SARA) interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor.
Formal Description
Interaction-ID: 56872

gene/protein

ZFYVE9

interacts (colocalizes) with

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment ZFYVE9 (SARA) interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor.
Formal Description
Interaction-ID: 56873

gene/protein

ZFYVE9

interacts (colocalizes) with

gene/protein

SMAD3

Comment Expression of SARA changes as the development of epithelial to mesenchymal transition (EMT) and fibrosis and it plays a critical role in the maintenance of epithelial cell phenotype.
Formal Description
Interaction-ID: 56874

gene/protein

ZFYVE9

affects_activity of

Comment ZFYVE9 (SARA) interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor.
Formal Description
Interaction-ID: 56875

gene/protein

ZFYVE9

increases_activity of

gene/protein

TGFB1

Drugbank entries Show/Hide entries for TGFB1
Comment ZFYVE9 (SARA) interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor.
Formal Description
Interaction-ID: 61036

gene/protein

ZFYVE9

increases_activity of

Comment ZFYVE9 (SARA) interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor.
Formal Description
Interaction-ID: 61037

gene/protein

SMAD2

increases_activity of

Drugbank entries Show/Hide entries for SMAD2