General Information:

Id: 6,033
Diseases: Lung disease
Pulmonary fibrosis, idiopathic - [OMIM]
Homo sapiens
IPF patients
lung alveolar type II cell
article
Reference: Marmai C et al.(2011) Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis Am. J. Physiol. Lung Cell Mol. Physiol. 301: L71-L78 [PMID: 21498628]

Interaction Information:

Comment TGF-beta receptor kinase inhibition maintained the epithelial phenotype of type II cells isolated from IPF lungs and blocks therefore EMT transition.
Formal Description
Interaction-ID: 56530

gene/protein

TGFB1

increases_activity of

Drugbank entries Show/Hide entries for TGFB1
Comment Alveolar type II cells isolated from the lungs of patients with IPF express higher levels of mRNA for the mesenchymal proteins type I collagen, alpha-smooth muscle actin (alpha-SMA), and calponin.
Formal Description
Interaction-ID: 56538

complex/PPI

Collagen I

is_expressed_in

tissue/cell line

alveolar epithelial cell, type II

of IPF patients
Comment Alveolar type II cells isolated from the lungs of patients with IPF express higher levels of mRNA for the mesenchymal proteins type I collagen, alpha-smooth muscle actin (alpha-SMA), and calponin.
Formal Description
Interaction-ID: 56539

gene/protein

ACTA2

is_expressed_in

tissue/cell line

alveolar epithelial cell, type II

of IPF patients
Comment Alveolar type II cells isolated from the lungs of patients with IPF express higher levels of mRNA for the mesenchymal proteins type I collagen, alpha-smooth muscle actin (alpha-SMA), and calponin.
Formal Description
Interaction-ID: 56541

gene/protein

CNN1

is_expressed_in

tissue/cell line

alveolar epithelial cell, type II

of IPF patients
Comment Since several mesenchyme-associated genes are expressed in some of the alveolar epithelial cell type II cells (AEC2) of IPF patients this suggests that AEC2 cells undergo epithelial to mesenchymal transition in IPF lung tissue.
Formal Description
Interaction-ID: 56545

increases_activity of

alveolar epithelial cells, type II of IPF patients
Comment TGF-beta receptor kinase inhibition maintained the epithelial phenotype of type II cells isolated from IPF lungs and blocks therefore EMT transition.
Formal Description
Interaction-ID: 73193