General Information:

Id: 5,931
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Babitt JL et al.(2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression Nat. Genet. 38: 531-539 [PMID: 16604073]

Interaction Information:

Comment Hemojuvelin enhances bone morphogenetic protein (BMP), but not TGF-beta, signaling.
Formal Description
Interaction-ID: 55986

gene/protein

HJV

increases_activity of

Comment Hemojuvelin enhances bone morphogenetic protein (BMP), but not TGF-beta, signaling.
Formal Description
Interaction-ID: 55991

gene/protein

HJV

NOT increases_activity of

Comment The data collectively suggest that Hjv.Fc binds to radiolabeled BMP-2 and, to a lesser extent, BMP-4.
Formal Description
Interaction-ID: 55993

gene/protein

HJV

interacts (colocalizes) with

gene/protein

BMP2

Comment The data collectively suggest that Hjv.Fc binds to radiolabeled BMP-2 and, to a lesser extent, BMP-4.
Formal Description
Interaction-ID: 55994

gene/protein

HJV

interacts (colocalizes) with

gene/protein

BMP4

Comment To examine whether hemojuvelin-mediated BMP signaling requires BMP receptors, the effects of dominant-negative mutant BMP type I receptors ALK3 and ALK6 were tested in the reporter assay system. These dominant-negative mutants are deficient in kinase activity and therefore unable to phosphorylate Smad proteins. BRE luciferase activity induced by transfection with Hjv or incubation of cells with exogenous BMP-2 was inhibited by coexpression with dominant-negative ALK3 or ALK6. Thus, hemojuvelin-mediated BMP signaling involves BMP type I receptors.
Formal Description
Interaction-ID: 55995

gene/protein

HJV

increases_activity of

gene/protein

BMPR1A

Comment To examine whether hemojuvelin-mediated BMP signaling requires BMP receptors, the effects of dominant-negative mutant BMP type I receptors ALK3 and ALK6 were tested in the reporter assay system. These dominant-negative mutants are deficient in kinase activity and therefore unable to phosphorylate Smad proteins. BRE luciferase activity induced by transfection with Hjv or incubation of cells with exogenous BMP-2 was inhibited by coexpression with dominant-negative ALK3 or ALK6. Thus, hemojuvelin-mediated BMP signaling involves BMP type I receptors.
Formal Description
Interaction-ID: 55996

gene/protein

HJV

increases_activity of

gene/protein

BMPR1B

Comment Hemojuvelin mediates BMP signaling via the classical BMP signaling pathway that involves BMP receptor-activated Smad1.
Formal Description
Interaction-ID: 55997

gene/protein

HJV

increases_activity of

gene/protein

SMAD1

Comment A common mutation in HFE2 that results in juvenile hemochromatosis is a point mutation substituting valine for glycine at amino acid 320 (corresponding to amino acid 313 in mouse hemojuvelin). cDNA encoding the equivalent mouse mutation, G313V-Hjv, was created. These hemojuvelin mutants have impaired BMP signaling ability.
Formal Description
Interaction-ID: 55998

decreases_activity of

Comment Hemojuvelin increases hepcidin expression in liver cells.
Formal Description
Interaction-ID: 55999

gene/protein

HJV

increases_expression of

gene/protein

HAMP

in liver
Comment BMP-2 increases hepcidin expression in liver cells.
Formal Description
Interaction-ID: 56000

gene/protein

BMP2

increases_expression of

gene/protein

HAMP

in liver