General Information:

Id: 580 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
brain
article
Reference: Phiel CJ et al.(2003) GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides Nature 423: 435-439 [PMID: 12761548]

Interaction Information:

Comment Selective reduction of GSK-3A protein expression decreased amyloid beta40 peptide (Abeta40) and amyloid beta42 peptide (Abeta42) levels. Reduction of GSK-3B protein levels resulted in a modest increase in Abeta40 and Abeta42 concentration. The amino- and carboxyterminal sequences of GSK-3A and GSK-3B are dissimilar. This divergence may account for functional differences in the regulation of APP processing.
Formal Description
Interaction-ID: 26738

gene/protein

GSK3A

increases_quantity of