General Information:

Id: 5,696 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, dilated
Mus musculus
article
Reference: Liang X et al.(2009) Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality Circulation 120: 568-576 [PMID: 19652092]

Interaction Information:

Comment Deletion of one of the component proteins of the ILK, Parvin, and PINCH complex leads to degradation of the others and impaired cell mobility and survival. The expression of a number of key proteins in the integrin pathway was examined in PINCH CDKO mutant myocardium. Western blotting revealed a dramatic reduction in expression of ILK and Parvin in CDKO cardiomyocytes at both postnatal days 1 and 10 compared with controls. Integrin-beta1 was expressed initially at normal levels at postnatal day 1 but was significantly reduced at day 10.
Formal Description
Interaction-ID: 54019

gene/protein

LIMS1

increases_expression of

gene/protein

ILK

in murine myocardium