General Information:

Id: 5,637
Diseases: Cancer
Mus musculus
article
Reference: Taylor CJ et al.(2011) Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells Surgery 150: 162-168 [PMID: 21719054]

Interaction Information:

Comment Transient silencing of ILK produced correlative decreases in PTEN expression, cell proliferation, and soft agar colony formation. Conversely, stably transfected ILK knockdown cells showed an increase in phospho-Akt levels, leading to cell proliferation. ILK plays an important role in the regulation of PI3K/Akt pathway via PTEN or an upstream effector ofPTEN.
Formal Description
Interaction-ID: 53864

gene/protein

ILK

increases_activity of

gene/protein

PTEN