General Information:

Id: 556
Diseases: Dementia, Lewy body - [OMIM]
Parkinson disease
Homo sapiens
BTO:0000142 brain; BTO:0000018 A-549 cell
article
Reference: Kawaguchi Y et al.(2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress Cell 6: 727-738 [PMID: 14675537]

Interaction Information:

Comment HDAC6 is concentrated in Lewy Bodies of Parkinson's Disease.
Formal Description
Interaction-ID: 2865

gene/protein

HDAC6

is localized in

Drugbank entries Show/Hide entries for HDAC6
Comment In untreated cells, the immunolocalization of HDAC6 displays a punctate cytoplasmic staining.
Formal Description
Interaction-ID: 2876

gene/protein

HDAC6

is localized in

cellular component

cytoplasm

Drugbank entries Show/Hide entries for HDAC6
Comment After treatment of cells with the proteasome inhibitor MG132, HDAC6 is localized to Aggresomes.
Formal Description
Interaction-ID: 2877

gene/protein

HDAC6

is localized in

cellular component

aggresome

after treatment with proteasome inhibitor MG132
Drugbank entries Show/Hide entries for HDAC6
Comment ER-stress-inducing agents cause aggresome formation and a relocalization of HDAC6 to aggresomes.
Formal Description
Interaction-ID: 2878

increases_transport of

gene/protein

HDAC6

into aggresome
Drugbank entries Show/Hide entries for HDAC6
Comment HDAC6 associates with the dynein motor complex and recruits polyubiquitinated proteins to dynein.
Formal Description
Interaction-ID: 2887

gene/protein

HDAC6

interacts (colocalizes) with

complex/PPI

Dynein complex

Drugbank entries Show/Hide entries for HDAC6
Comment HDAC6 associates with the dynein motor complex and recruits polyubiquitinated proteins to dynein.
Formal Description
Interaction-ID: 2889

gene/protein

HDAC6

increases_activity of

Drugbank entries Show/Hide entries for HDAC6
Comment HDAC6 is required for Aggresome formation.
Formal Description
Interaction-ID: 2890

gene/protein

HDAC6

increases_activity of

Drugbank entries Show/Hide entries for HDAC6
Comment Loss of HDAC6 leads to hypersensitivity to misfolded protein-induced stress.
Formal Description
Interaction-ID: 2892

gene/protein

HDAC6

affects_activity of

Drugbank entries Show/Hide entries for HDAC6