General Information:

Id: 5,518
Diseases: Cardiomyopathy, dilated
Mus musculus
article
Reference: White DE et al.(2006) Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure Genes Dev. 20: 2355-2360 [PMID: 16951252]

Interaction Information:

Comment Through the phosphorylation of downstream targets such as Akt and GSK-3beta, ILK was shown to promote oncogenic transformation through the induction of anti-apoptotic pathways and cell cycle progression (cited information).
Formal Description
Interaction-ID: 53474

gene/protein

ILK

increases_phosphorylation of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Using an antibody specific for phospho-Tyr 576 in the kinase domain of FAK, we found that phosphorylation of this residue was not induced in the ILK-null hearts of mckCRE ILKfl/fl mice . Phosphorylation of this residue normally occurs after FAK is recruited to beta1-integrin-containing adhesion complexes, and is required for activation of FAK kinase activity.
Formal Description
Interaction-ID: 53794

gene/protein

PTK2

interacts (colocalizes) with

gene/protein

ITGB1

in cardiac tissue
Drugbank entries Show/Hide entries for PTK2 or ITGB1
Comment Using an antibody specific for phospho-Tyr 576 in the kinase domain of FAK, we found that phosphorylation of this residue was not induced in the ILK-null hearts of mckCRE ILKfl/fl mice . Phosphorylation of this residue normally occurs after FAK is recruited to beta1-integrin-containing adhesion complexes, and is required for activation of FAK kinase activity.
Formal Description
Interaction-ID: 53795

gene/protein

ILK

increases_phosphorylation of

complex/PPI

ITGB1-PTK2 complex

in cardiac tissue
Comment Using an antibody specific for phospho-Tyr 576 in the kinase domain of FAK, we found that phosphorylation of this residue was not induced in the ILK-null hearts of mckCRE ILKfl/fl mice . Phosphorylation of this residue normally occurs after FAK is recruited to beta1-integrin-containing adhesion complexes, and is required for activation of FAK kinase activity.
Formal Description
Interaction-ID: 53796

gene/protein

PTK2

is_part_of

complex/PPI

ITGB1-PTK2 complex

in cardiac tissue
Drugbank entries Show/Hide entries for PTK2
Comment Using an antibody specific for phospho-Tyr 576 in the kinase domain of FAK, we found that phosphorylation of this residue was not induced in the ILK-null hearts of mckCRE ILKfl/fl mice . Phosphorylation of this residue normally occurs after FAK is recruited to beta1-integrin-containing adhesion complexes, and is required for activation of FAK kinase activity.
Formal Description
Interaction-ID: 53797

gene/protein

ITGB1

is_part_of

complex/PPI

ITGB1-PTK2 complex

in cardiac tissue
Drugbank entries Show/Hide entries for ITGB1