General Information:

Id: 5,512
Diseases: Emery-Dreifuss muscular dystrophy
Metabolic
Homo sapiens
article
Reference: Koch AJ and Holaska JM(2012) Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors PLoS ONE 7 [PMID: 22606356]

Interaction Information:

Comment The muscle wasting phenotype of EDMD is caused by defective myogenic progenitor cell differentiation and impaired muscle regeneration. Components of the Wnt, IGF-1, TGF-beta, and Notch signaling pathways are misexpressed in emerin-null myogenic progenitors at both the mRNA and protein levels.
Formal Description
Interaction-ID: 53458

gene/protein

EMD

affects_activity of

Comment The muscle wasting phenotype of EDMD is caused by defective myogenic progenitor cell differentiation and impaired muscle regeneration. Components of the Wnt, IGF-1, TGF-beta, and Notch signaling pathways are misexpressed in emerin-null myogenic progenitors at both the mRNA and protein levels.
Formal Description
Interaction-ID: 53460

gene/protein

EMD

affects_activity of

process

IGF signaling pathway

Comment The muscle wasting phenotype of EDMD is caused by defective myogenic progenitor cell differentiation and impaired muscle regeneration. Components of the Wnt, IGF-1, TGF-beta, and Notch signaling pathways are misexpressed in emerin-null myogenic progenitors at both the mRNA and protein levels.
Formal Description
Interaction-ID: 53461

gene/protein

EMD

affects_activity of

Comment The muscle wasting phenotype of EDMD is caused by defective myogenic progenitor cell differentiation and impaired muscle regeneration. Components of the Wnt, IGF-1, TGF-beta, and Notch signaling pathways are misexpressed in emerin-null myogenic progenitors at both the mRNA and protein levels.
Formal Description
Interaction-ID: 53462

gene/protein

EMD

affects_activity of