General Information:

Id: 5,232
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000599 Hep-G2 cell
article
Reference: Ramos AA et al.(2008) Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay Toxicol. Lett. 177: 66-73 [PMID: 18276086]

Interaction Information:

Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50952

drug/chemical compound

Quercetin

decreases_activity of

Drugbank entries Show/Hide entries for Quercetin
Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50953

drug/chemical compound

Ursolic acid

decreases_activity of

Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50954

drug/chemical compound

Quercetin

decreases_activity of

Drugbank entries Show/Hide entries for Quercetin
Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50955

drug/chemical compound

Ursolic acid

decreases_activity of

Comment Quercetin and ursolic acid increased the rate of DNA repair.
Formal Description
Interaction-ID: 50956

drug/chemical compound

Quercetin

increases_activity of

process

DNA repair

Drugbank entries Show/Hide entries for Quercetin
Comment Quercetin and ursolic acid increased the rate of DNA repair.
Formal Description
Interaction-ID: 50957

drug/chemical compound

Ursolic acid

increases_activity of

process

DNA repair

Comment Rutin did not have effects on DNA damage, proliferation or DNA repair at any level.
Formal Description
Interaction-ID: 50958

drug/chemical compound

Rutin

NOT affects_activity of

Drugbank entries Show/Hide entries for Rutin
Comment Rutin did not have effects on DNA damage, proliferation or DNA repair at any level.
Formal Description
Interaction-ID: 50959

drug/chemical compound

Rutin

NOT affects_activity of

Drugbank entries Show/Hide entries for Rutin
Comment Rutin did not have effects on DNA damage, proliferation or DNA repair at any level.
Formal Description
Interaction-ID: 50960

drug/chemical compound

Rutin

NOT affects_activity of

process

DNA repair

Drugbank entries Show/Hide entries for Rutin