General Information:

Id: 518
Diseases: Parkinson disease
Homo sapiens
BTO:0002104 BE(2)M17 cell
article
Reference: Sandebring A et al.(2009) Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS ONE 4: E5701 [PMID: 19492085]

Interaction Information:

Comment Cells transduced with PINK1 shRNA lentivirus showed decreased mitochondrial membrane potential, suggesting that PINK1 is involved in regulating the membrane potential of mitochondia.
Formal Description
Interaction-ID: 2570

gene/protein

PINK1

affects_activity of

Comment PINK1 can protect against rotenone toxicity, since cells expressing PINK1 showed improved viability after exposure of rotenone.
Formal Description
Interaction-ID: 2661

drug/chemical compound

Rotenone

increases_activity of

process

neuron death

Comment PINK1 can protect against rotenone toxicity, since cells expressing PINK1 showed improved viability after exposure of rotenone.
Formal Description
Interaction-ID: 2662

gene/protein

PINK1

decreases_activity of

drug/chemical compound

Rotenone

Comment PINK1 can protect against rotenone toxicity, since cells expressing PINK1 showed improved viability after exposure of rotenone.
Formal Description
Interaction-ID: 2664

gene/protein

PINK1

decreases_activity of

process

neuron death

if cell death has been induced by rotenone
Comment Rotenone is a stress-inducing agent shown to cause mitochondrial truncation and fragmentation.
Formal Description
Interaction-ID: 2665

drug/chemical compound

Rotenone

increases_activity of

Comment Increased expression of wild type PINK1 limited the number of cells with fragmented/truncated mitochondria after exposure of rotenone.
Formal Description
Interaction-ID: 2667

gene/protein

PINK1

decreases_activity of

after exposure of rotenone
Comment Overexpression of DRP1 in PINK1-deficient cells caused more disrupted mitochondrial networks, suggesting that loss of PINK1 and overexpression of DRP1 have additive effects.
Formal Description
Interaction-ID: 2669

gene/protein

DNM1L

increases_activity of

Comment DRP1 was recruited to foci on the surface of mitochondria.
Formal Description
Interaction-ID: 2670

gene/protein

DNM1L

is localized in

cellular component

mitochondrion

Comment Overexpression of PINK1 limits DRP1-mediated mitochondrial fragmentation.
Formal Description
Interaction-ID: 2674

gene/protein

PINK1

decreases_activity of

gene/protein

DNM1L

Comment DRP1 showed a loss of phosphorylation in the absence of PINK1, but there was no difference in phosphorylated amounts of OPA1, MFN1, MFN2 and HTRA2.
Formal Description
Interaction-ID: 2678

gene/protein

PINK1

affects_phosphorylation of

gene/protein

DNM1L

Comment DRP1 showed a loss of phosphorylation in the absence of PINK1, but there was no difference in phosphorylated amounts of OPA1, MFN1, MFN2 and HTRA2.
Formal Description
Interaction-ID: 2679

gene/protein

PINK1

NOT affects_phosphorylation of

gene/protein

OPA1

Comment DRP1 showed a loss of phosphorylation in the absence of PINK1, but there was no difference in phosphorylated amounts of OPA1, MFN1, MFN2 and HTRA2.
Formal Description
Interaction-ID: 2680

gene/protein

PINK1

NOT affects_phosphorylation of

gene/protein

MFN1

Comment DRP1 showed a loss of phosphorylation in the absence of PINK1, but there was no difference in phosphorylated amounts of OPA1, MFN1, MFN2 and HTRA2.
Formal Description
Interaction-ID: 2681

gene/protein

PINK1

NOT affects_phosphorylation of

gene/protein

HTRA2

Comment DRP1 showed a loss of phosphorylation in the absence of PINK1, but there was no difference in phosphorylated amounts of OPA1, MFN1, MFN2 and HTRA2.
Formal Description
Interaction-ID: 2682

gene/protein

PINK1

NOT affects_phosphorylation of

gene/protein

MFN2

Comment Calcineurin increases DRP1 activity via its phosphatase activity.
Formal Description
Interaction-ID: 2683

complex/PPI

Calcineurin

increases_activity of

gene/protein

DNM1L

Comment Calcineurin increases DRP1 activity via its phosphatase activity.
Formal Description
Interaction-ID: 2684

complex/PPI

Calcineurin

decreases_phosphorylation of

gene/protein

DNM1L

Comment Calcineurin activity was significantly increased in PINK1 deficient cells.
Formal Description
Interaction-ID: 2689

gene/protein

PINK1

affects_activity of

complex/PPI

Calcineurin