General Information:

Id: 4,889 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mus musculus
Cav1-/-
article
Reference: Murata T et al.(2007) Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice J. Exp. Med. 204: 2373-2382 [PMID: 17893196]

Interaction Information:

Comment Both Cav-1 and -2 levels are reduced in Cav1-KO pulmonary arteries. However, Cav-3, beta-actin, eNOS, HSP90, and the protein kinase Akt levels are not affected.
Formal Description
Interaction-ID: 48107

gene/protein

CAV1

NOT affects_quantity of

gene/protein

CAV3

in pulmonary arteries
Comment Cardiac and pulmonary tissue contained all three Cav isoforms, with more Cav-3 in the heart and more Cav-1 and -2 in the lung.
Formal Description
Interaction-ID: 48119

gene/protein

CAV3

is_expressed_in

tissue/cell line

heart

Comment Cardiac and pulmonary tissue contained all three Cav isoforms, with more Cav-3 in the heart and more Cav-1 and -2 in the lung.
Formal Description
Interaction-ID: 48122

gene/protein

CAV3

is_expressed_in

tissue/cell line

lung