General Information:

Id: 4,843
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0002418 NCI-H292 cell
article
Reference: Chang Y et al.(2005) KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells J. Lipid Res. 46: 2624-2635 [PMID: 16162944]

Interaction Information:

Comment Overexpression of active SREBP-1 directly stimulated SCD-1 and FAS.
Formal Description
Interaction-ID: 47771

gene/protein

SREBF1

increases_expression of

gene/protein

SCD

Comment Overexpression of active SREBP-1 directly stimulated SCD-1 and FAS.
Formal Description
Interaction-ID: 47772

gene/protein

SREBF1

increases_expression of

gene/protein

FASN

Drugbank entries Show/Hide entries for FASN
Comment Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a pulmonary epithelial cancer cell line.
Formal Description
Interaction-ID: 47840

gene/protein

FGF7

increases_activity of

Comment Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a pulmonary epithelial cancer cell line.
Formal Description
Interaction-ID: 47841

gene/protein

FGF7

increases_activity of

Comment In H292 cells, KGF stimulated ERK kinase, as demonstrated by protein phosphorylation. Peak activation occurred after 10 min of exposure. Generally, growth factors stimulate the phosphorylation of two members of the p42/p44 family, the extracellular regulated kinases [ERK-1 (p44) and ERK-2 (p42)]. However, in H292 cells, it appears that KGF activates p42 but not p44.
Formal Description
Interaction-ID: 47842

gene/protein

FGF7

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment KGF activated Akt and p70 S6K, which are downstream targets of PI3K.
Formal Description
Interaction-ID: 47843

gene/protein

FGF7

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment KGF activated Akt and p70 S6K, which are downstream targets of PI3K.
Formal Description
Interaction-ID: 47844

gene/protein

FGF7

increases_activity of

gene/protein

RPS6KB1

Comment KGF activated the phosphorylation of JNK1.
Formal Description
Interaction-ID: 47845

gene/protein

FGF7

increases_activity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment KGF stimulated the expression of the transcription factors sterol-regulatory element binding protein-1 (SREBP-1), CCAAT/enhancer binding protein alpha (C/EBPalpha), and C/EBPdelta and two key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1).
Formal Description
Interaction-ID: 47846

gene/protein

FGF7

increases_expression of

gene/protein

SREBF1

Comment KGF stimulated the expression of the transcription factors sterol-regulatory element binding protein-1 (SREBP-1), CCAAT/enhancer binding protein alpha (C/EBPalpha), and C/EBPdelta and two key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1).
Formal Description
Interaction-ID: 47848

gene/protein

FGF7

increases_expression of

gene/protein

CEBPA

Comment KGF stimulated the expression of the transcription factors sterol-regulatory element binding protein-1 (SREBP-1), CCAAT/enhancer binding protein alpha (C/EBPalpha), and C/EBPdelta and two key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1).
Formal Description
Interaction-ID: 47849

gene/protein

FGF7

increases_expression of

gene/protein

CEBPD

Comment KGF stimulated the expression of the transcription factors sterol-regulatory element binding protein-1 (SREBP-1), CCAAT/enhancer binding protein alpha (C/EBPalpha), and C/EBPdelta and two key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1).
Formal Description
Interaction-ID: 47850

gene/protein

FGF7

increases_expression of

gene/protein

FASN

Drugbank entries Show/Hide entries for FASN
Comment KGF stimulated the expression of the transcription factors sterol-regulatory element binding protein-1 (SREBP-1), CCAAT/enhancer binding protein alpha (C/EBPalpha), and C/EBPdelta and two key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1).
Formal Description
Interaction-ID: 47851

gene/protein

FGF7

increases_expression of

gene/protein

SCD

Comment Exogenous cholesterol inhibits the induction of FAS and SCD-1 expression by KGF.
Formal Description
Interaction-ID: 47853

drug/chemical compound

Cholesterol

decreases_expression of

gene/protein

FASN

Drugbank entries Show/Hide entries for Cholesterol or FASN
Comment Exogenous cholesterol inhibits the induction of FAS and SCD-1 expression by KGF.
Formal Description
Interaction-ID: 47855

drug/chemical compound

Cholesterol

decreases_expression of

gene/protein

SCD

Drugbank entries Show/Hide entries for Cholesterol