General Information:

Id: 4,308
Diseases: Metabolic
Homo sapiens
BTO:0000007 HEK-293 cell; BTO:0002181 HEK-293T cell
article
Reference: Zhou F et al.(2011) Wnt/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity Biochem. Biophys. Res. Commun. 412: 68-73 [PMID: 21798242]

Interaction Information:

Comment Wnt/beta-catenin stabilizes endogenous AICD by increasing the protein half-life.
Formal Description
Interaction-ID: 44132

increases_quantity of

due to the increased protein stability by Wnt/beta-catenin
Comment Beta-catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity.
Formal Description
Interaction-ID: 44133

gene/protein

CTNNB1

interacts (colocalizes) with

Drugbank entries Show/Hide entries for CTNNB1
Comment Beta-catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity.
Formal Description
Interaction-ID: 44134

gene/protein

CTNNB1

increases_activity of

Drugbank entries Show/Hide entries for CTNNB1
Comment Investigation by AICD mutants proved that Fe65, a previously identified AICD binding partner, is not involved in the regulation of AICD mediated transcriptional activity. Wnt/beta-catenin stabilizes AICD independent of Fe65. AICD contains a Fe65 interacting motif (YENPTY) and a critical phosphorylation site (T) in position 668 (APP695 isoform numbering).
Formal Description
Interaction-ID: 44135

gene/protein

APBB1

NOT affects_activity of

concerning the regulation of AICD mediated transcriptional activity by Wnt/beta-catenin
Comment Wnt-1 had no effect on the total expression of APP but resulted in a threefold increase of sAPPalpha production, indicating that alpha-secretase activity was stimulated by Wnt-1.
Formal Description
Interaction-ID: 44136

gene/protein

WNT1

NOT affects_expression of

gene/protein

APP

but increases the sAPPalpha production, indicating that alpha-secretase activity was stimulated by Wnt-1
Drugbank entries Show/Hide entries for APP
Comment Wnt-1 had no effect on the total expression of APP but resulted in a threefold increase of sAPPalpha production, indicating that alpha-secretase activity was stimulated by Wnt-1.
Formal Description
Interaction-ID: 44137

gene/protein

WNT1

increases_quantity of

gene/protein

sAPP-alpha

by stimulating the alpha-secretase activity
Comment Wnt-1 had no effect on the total expression of APP but resulted in a threefold increase of sAPPalpha production, indicating that alpha-secretase activity was stimulated by Wnt-1.
Formal Description
Interaction-ID: 44138

gene/protein

WNT1

increases_activity of

gene/protein

Alpha-secretase

resulting in an increase of sAPPalpha production
Comment Wnt/beta-catenin signaling enhances the transcriptional activity of AICD.
Formal Description
Interaction-ID: 44139

increases_activity of

concerning the transcriptional activity of AICD
Comment Wnt-1 is part of the Wnt receptor signaling pathway.
Formal Description
Interaction-ID: 44600

gene/protein

WNT1

increases_activity of