General Information:

Id: 4,142
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Ochiai D et al.(2011) Disruption of HIF-1alpha in hepatocytes impairs glucose metabolism in diet-induced obesity mice Biochem. Biophys. Res. Commun. 415: 445-449 [PMID: 22051049]

Interaction Information:

Comment Exposure to high fat/sucrose diet (HFSD) for 5 weeks elicited liver hypoxia with a transient increase in HIF-1alpha protein expression in the liver of control mice.
Formal Description
Interaction-ID: 42735

environment

high-fat high-sucrose diet

increases_activity of

in liver
Comment Exposure to high fat/sucrose diet (HFSD) for 5 weeks elicited liver hypoxia with a transient increase in HIF-1alpha protein expression in the liver of control mice.
Formal Description
Interaction-ID: 42741

increases_expression of

gene/protein

HIF1A

in liver
Drugbank entries Show/Hide entries for HIF1A
Comment In control mice exposed to high fat/sucrose diet (HFSD) for 5 weeks, relative amounts of glucokinase (GK), phosphoglycerate kinase-1 (PGK) and pyruvate kinase L (PK) were elevated to varied degree, while those of phosphoenolpyruvate carboxykinase (PEPCK) were greatly reduced.
Formal Description
Interaction-ID: 42743

environment

high-fat high-sucrose diet

increases_expression of

gene/protein

GCK

in liver
Drugbank entries Show/Hide entries for GCK
Comment In control mice exposed to high fat/sucrose diet (HFSD) for 5 weeks, relative amounts of glucokinase (GK), phosphoglycerate kinase-1 (PGK) and pyruvate kinase L (PK) were elevated to varied degree, while those of phosphoenolpyruvate carboxykinase (PEPCK) were greatly reduced.
Formal Description
Interaction-ID: 42744

environment

high-fat high-sucrose diet

increases_expression of

gene/protein

PGK1

in liver
Drugbank entries Show/Hide entries for PGK1
Comment In control mice exposed to high fat/sucrose diet (HFSD) for 5 weeks, relative amounts of glucokinase (GK), phosphoglycerate kinase-1 (PGK) and pyruvate kinase L (PK) were elevated to varied degree, while those of phosphoenolpyruvate carboxykinase (PEPCK) were greatly reduced.
Formal Description
Interaction-ID: 42745

environment

high-fat high-sucrose diet

increases_expression of

gene/protein

PKLR

in liver
Drugbank entries Show/Hide entries for PKLR
Comment In control mice exposed to high fat/sucrose diet (HFSD) for 5 weeks, relative amounts of glucokinase (GK), phosphoglycerate kinase-1 (PGK) and pyruvate kinase L (PK) were elevated to varied degree, while those of phosphoenolpyruvate carboxykinase (PEPCK) were greatly reduced.
Formal Description
Interaction-ID: 42746

environment

high-fat high-sucrose diet

decreases_expression of

gene/protein

PCK1

in liver
Drugbank entries Show/Hide entries for PCK1