General Information:

Id: 381 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Edbauer D et al.(2002) Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc. Natl. Acad. Sci. U.S.A. 99: 8666-8671 [PMID: 12048259]

Interaction Information:

Comment Down-regulation of nicastrin by RNAi levels leads to a massive accumulation of the C-terminal fragments of the beta-amyloid precursor protein (APP); in addition, amyloid-beta production was markedly reduced (Abeta40 and Abeta42) by about 60%.
Formal Description
Interaction-ID: 14074

gene/protein

NCSTN

affects_quantity of

NCSTN acts as member of gamma-secretase complex (CorumID: 466)
Comment beta-Secretase and gamma-secretase affect the quantity of the different amyloid beta peptide types (Abeta40 and Abeta42) via processing of APP.
Formal Description
Interaction-ID: 21385

affects_quantity of