General Information:

Id: 378
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
GPAT1-/- mouse
article
Reference: Yazdi M et al.(2008) The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice Biochem. Biophys. Res. Commun. 369: 1065-1070 [PMID: 18339309]

Interaction Information:

Comment Feeding wild-type mice a high-fat diet for 14 weeks increased the microsomal GPAT activity by 31% and tended to increase mitochondrial GPAT activity (23%) in total liver membrane fractions. Mitochondrial GPAT activity was reduced by 85% in GPAT1-/- mice fed chow diet and by about 93% when fed a high-fat diet, compared to respective wild-type controls. Microsomal GPAT activity was reduced by 50% or 45% in GPAT1-/- mice when fed either chow or high-fat diet, respectively compared with wild-type controls. Thus, the generated GPAT1-/- mice lack GPAT1 protein and have markedly reduced mitochondrial GPAT activity but also reduced microsomal GPAT activity.
Formal Description
Interaction-ID: 1541

environment

high-fat diet

affects_activity of

gene/protein

GPAT

Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 1542

gene/protein

GPAM

affects_activity of

disease

Obesity

in female mice fed chow diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 1543

gene/protein

GPAM

NOT affects_activity of

disease

Obesity

in male mice fed either chow or long-term high-fat diet
Comment GPAT1-deficiency does not protect against high-fat diet induced obesity, hepatic steatosis or whole body glucose intolerance.
Formal Description
Interaction-ID: 1544

gene/protein

GPAM

NOT affects_activity of

disease

Fatty liver disease, nonalcoholic

if hepatic steatosis is high-fat diet-induced
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12648

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Triacylglycerol

in liver, in blood; in female mice fed chow diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12649

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Cholesterol

in blood; in female mice fed chow diet
Drugbank entries Show/Hide entries for
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12651

gene/protein

GPAM

affects_activity of

in liver; in female mice fed chow diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12653

gene/protein

GPAM

affects_activity of

in female mice fed chow diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12654

gene/protein

GPAM

NOT affects_activity of

disease

Obesity

in female mice after long-term high-fat diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12656

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Triacylglycerol

in liver, in blood; in female mice after long-term high-fat diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12657

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Cholesterol

in blood; in female mice after long-term high-fat diet
Drugbank entries Show/Hide entries for
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12659

gene/protein

GPAM

NOT affects_activity of

in liver; in female mice after long-term high-fat diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12660

gene/protein

GPAM

NOT affects_activity of

in female mice after long-term high-fat diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12664

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Triacylglycerol

in liver, in blood; in male mice fed either chow or long-term high-fat diet
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12666

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Cholesterol

in blood; in male mice fed either chow or long-term high-fat diet
Drugbank entries Show/Hide entries for
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12667

gene/protein

GPAM

NOT affects_activity of

in liver; in male mice fed either chow or long-term high-fat
Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12668

gene/protein

GPAM

affects_activity of

in male mice fed either chow or long-term high-fat
Comment GPAT1-deficiency does not protect against high-fat diet induced obesity, hepatic steatosis or whole body glucose intolerance.
Formal Description
Interaction-ID: 12669

gene/protein

GPAM

NOT affects_activity of

if glucose intolerance is high-fat diet-induced