General Information:

Id: 3,671 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Natella F and Scaccini C(2012) Role of coffee in modulation of diabetes risk Nutr. Rev. 70: 207-217 [PMID: 22458694]

Interaction Information:

Comment Several mechanisms were proposed to explain how chlorogenic acid could affect glucose homeostasis. In an in vitro study conducted on vesicles of rat intestine membrane, chlorogenic acid reduced the intestinal absorption of glucose through inhibition of Na+-dependent glucose transporter. A study using the same experimental model demonstrated that caffeic acid has a weak inhibitory activity against sucrase activity (an enzyme involved in the digestion of carbohydrates). In in vitro studies conducted on rat and human liver microsomes, chlorogenic acid was able to inhibit glucose 6-phosphatase, a key enzyme in the production of glucose in the liver. Finally, in a cellular model, chlorogenic acid enhanced the uptake of glucose by myotubes through the increased expression of the glucose transporter GLUT4.
Formal Description
Interaction-ID: 35188

drug/chemical compound

Chlorogenate

increases_expression of

gene/protein

SLC2A4