General Information:

Id: 3,559
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Homo sapiens
article
Reference: Huffman KM et al.(2009) Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women Diabetes Care 9: 1678-1683 [PMID: 19502541]

Interaction Information:

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33067

phenotype

abnormal large neutral amino acid level

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33069

drug/chemical compound

Proline

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33070

drug/chemical compound

Valine

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33071

drug/chemical compound

Leucine/Isoleucine

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33072

drug/chemical compound

Methionine

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33073

drug/chemical compound

Phenylalanine

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33074

drug/chemical compound

Tyrosine

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33078

drug/chemical compound

Urate

affects_activity of

phenotype

decreased insulin sensitivity

Comment The 75 metabolic intermediates clustered into 19 factors comprising biologically related intermediates. A factor containing large neutral amino acids (Proline, Valine, Leucine/Isoleucine, Methionine, Phenylalanine, Tyrosine, Uric acid, and Histidine) was inversely related to insulin sensitivity. This single factor predicted 26% of the variance in insulin sensitivity. These findings are consistent with another study in which a branched-chain amino acid (BCAA)-related factor that included leucine/isoleucine, valine, phenylalanine, and tyrosine was the one most strongly associated with a different measure of insulin sensitivity.
Formal Description
Interaction-ID: 33081

drug/chemical compound

Histidine

affects_activity of

phenotype

decreased insulin sensitivity

Comment A factor containing fatty acids (FA-C14:0, FA-C16:1, FA-C16:0, FA-alpha-C18:3, FA-C18:2, FA-C18:1, FA-C18:0, FA-C22:6) and by-products of fatty acid oxidation was inversely related to the acute insulin response to glucose.
Formal Description
Interaction-ID: 33082
Comment A factor containing fatty acids (FA-C14:0, FA-C16:1, FA-C16:0, FA-alpha-C18:3, FA-C18:2, FA-C18:1, FA-C18:0, FA-C22:6) and by-products of fatty acid oxidation was inversely related to the acute insulin response to glucose.
Formal Description
Interaction-ID: 33085