General Information:

Id: 3,505
Diseases: Neurological
Homo sapiens
BTO:0000567 Hela
article
Reference: Kuratomi G et al.(2005) NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Biochem. J. 386: 461-470 [PMID: 15496141]

Interaction Information:

Comment NEDD4-2 interacts with TbetaR-I, and induces its ubiquitination and degradation.
Formal Description
Interaction-ID: 32518

gene/protein

NEDD4L

increases_ubiquitination/sumoylation of

gene/protein

TGFBR1

Drugbank entries Show/Hide entries for TGFBR1
Comment NEDD4-2 interacts with TbetaR-I, and induces its ubiquitination and degradation.
Formal Description
Interaction-ID: 32519

gene/protein

NEDD4L

decreases_quantity of

gene/protein

TGFBR1

Drugbank entries Show/Hide entries for TGFBR1
Comment NEDD4-2 induces the ubiquitination and degradaton of SMAD2.
Formal Description
Interaction-ID: 32520

gene/protein

NEDD4L

decreases_quantity of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment NEDD4-2 induces the ubiquitination and degradaton of SMAD2.
Formal Description
Interaction-ID: 32521

gene/protein

NEDD4L

increases_ubiquitination/sumoylation of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment Decreased expression level of NEDD4-2 results in enhancement of TGF-beta and BMP signalling.
Formal Description
Interaction-ID: 32522

gene/protein

NEDD4L

decreases_activity of

Comment Decreased expression level of NEDD4-2 results in enhancement of TGF beta and BMP signalling.
Formal Description
Interaction-ID: 32523

gene/protein

NEDD4L

decreases_activity of