General Information:

Id: 3,464
Diseases: Graft-versus-host disease - [OMIM]
Homo sapiens
BTO:0000661 Jukart cell
article
Reference: Tzachanis D et al.(2007) Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes Blood 109: 2944-2952 [PMID: 17164348]

Interaction Information:

Comment TOB selectively suppressed expression of TSG in T-cells.
Formal Description
Interaction-ID: 32275

gene/protein

TOB1

decreases_expression of

gene/protein

TWSG1

Comment TSG induced phosphorylation of the TGF-beta specific SMAD2 and enhanced TGF-beta mediated responses.
Formal Description
Interaction-ID: 32276

gene/protein

TWSG1

increases_phosphorylation of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment TSG induced phosphorylation of the TGF-beta specific SMAD2 and enhanced TGF-beta mediated responses.
Formal Description
Interaction-ID: 32277

gene/protein

SMAD2

increases_activity of

Drugbank entries Show/Hide entries for SMAD2
Comment TSG enhanced DNA-binding activity on Smad3/4 consensus sites induced by TGFbeta.
Formal Description
Interaction-ID: 32279

gene/protein

TWSG1

increases_activity of

gene/protein

SMAD3

Comment TSG enhanced DNA-binding activity on Smad3/4 consensus sites induced by TGF beta.
Formal Description
Interaction-ID: 32280

gene/protein

TWSG1

increases_activity of

gene/protein

SMAD4

Comment TSG enhanced DNA-binding activity on Smad3/4 consensus sites induced by TGFbeta.
Formal Description
Interaction-ID: 32285

gene/protein

TGFB1

increases_expression of

gene/protein

SMAD3

Drugbank entries Show/Hide entries for TGFB1
Comment Tsg did not affect phosphorylation of the BMP-specific Smad1.
Formal Description
Interaction-ID: 32428

gene/protein

TWSG1

NOT affects_phosphorylation of

gene/protein

SMAD1