General Information:

Id: 3,397
Diseases: Major depressive disorder - [OMIM]
Neurological
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Lin X et al.(2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling Cell 125: 915-928 [PMID: 16751101]

Interaction Information:

Comment PPM1A dephosphorylates SMAD2/3 terminating TGFbeta signaling (potentially associated with depression).
Formal Description
Interaction-ID: 31566

gene/protein

PPM1A

decreases_phosphorylation of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment PPM1A dephosphorylates SMAD2/3 and terminating TGFbeta signaling (potentially associated with depression).
Formal Description
Interaction-ID: 31567

gene/protein

PPM1A

decreases_phosphorylation of

gene/protein

SMAD3

Comment PPM1A dephosphorylates SMAD2/3 and terminating TGFbeta signaling (potentially associated with depression).
Formal Description
Interaction-ID: 31568

gene/protein

SMAD2

decreases_activity of

Drugbank entries Show/Hide entries for SMAD2
Comment PPM1A dephosphorylates SMAD2/3 and terminating TGFbeta signaling (potentially associated with depression).
Formal Description
Interaction-ID: 31569

gene/protein

SMAD3

decreases_activity of

Comment PPM1A dephosphorylates SMAD2/3 terminating TGFbeta signaling (potentially associated with depression).
Formal Description
Interaction-ID: 32592

gene/protein

PPM1A

decreases_activity of