General Information:

Id: 3,312 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
glucocorticoid-induced diabetic KK mouse
Reference: Bhat BG et al.(2008) Antisense inhibition of 11betahydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model Biochem. Biophys. Res. Commun. 365: 740-745 [PMID: 18029262]

Interaction Information:

Comment A novel glucocorticoid-induced diabetic KK mouse model was developed and 11betaHSD1 antisense oligonucleotide (ASO) was used as an inhibitory tool. KK mice were treated with 11betaHSD1 ASO for 28 days. On day 25, cortisone pellets were surgically implanted to induce diabetes. In the ASO-treated mice, plasma blood glucose levels were significantly reduced by up to 54%. In parallel, cortisol and other diabetes endpoints were also significantly reduced. Hepatic 11betaHSD1 mRNA was suppressed by up to 84% with a concomitant respective decrease of up to 49% in the expression of PEPCK. The results suggest that inhibition of 11betaHSD1 activity reduces the availability of cortisol to activate the glucocorticoid receptor, down regulates gluconeogenesis and thus reduces plasma glucose levels in cortisone-induced diabetic KK mice.
Formal Description
Interaction-ID: 30411



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