General Information:

Id: 3,050 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Sankar R et al.(2002) Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain. Brain Res. Mol. Brain Res. 107: 157-165 [PMID: 12425944]

Interaction Information:

Comment Both GLUT4 and GLUT8 are present in the developing mouse brain, with highest concentrations noted during the suckling phase. Although GLUT4 and GLUT8 immunoreactivity was found in many structures, most striking was the presence of GLUT8 in neurons of the substantia nigra and of great biological significance was the presence of both GLUT4 and GLUT8 in the hippocampus and hypothalamic paraventricular and arcuate nuclei. Thus, in addition to mediating insulin's effect on food intake, GLUT4 and GLUT8 may translate the effect of insulin, insulin-like substances, or insulin-like growth factors in regulating cognition and memory, emotional behavior, motor activity and seizures. GLUT8 may be the somatodendritic glucose transporter isoform in conjunction with the axonal GLUT3 isoform that mediates glucose transport necessary for neuronal function.
Formal Description
Interaction-ID: 28002




tissue/cell line

arcuate nucleus