General Information:

Id: 3,044
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Major depressive disorder - [OMIM]
Homo sapiens
Reference: Khani S and Tayek JA(2001) Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin. Sci. 101: 739-747 [PMID: 11724664]

Interaction Information:

Comment Direct effects of cortisol on gluconeogenesis and other parameters of insulin resistance were determined in normal subjects. Cortisol administration in humans increases GP by stimulating gluconeogenesis. Smaller increases in serum cortisol may contribute to the abnormal glucose metabolism known to occur in the metabolic syndrome.
Formal Description
Interaction-ID: 27980

drug/chemical compound


increases_activity of



in liver