General Information:

Id: 2,984
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Buttar NS et al.(2010) Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis J Biol Chem 285 [PMID: 20154088]

Interaction Information:

Comment Cytosolic phospholipase A2alpha (cPLA2alpha) is a rate-limiting enzyme involved in the regulation of prostaglandin E2 (PGE2) synthesis. KLF11 represses cPLA2alpha and down-regulates PGE2 synthesis.
Formal Description
Interaction-ID: 27190

gene/protein

PLA2G4A

increases_activity of

Drugbank entries Show/Hide entries for PLA2G4A
Comment Cytosolic phospholipase A2alpha (cPLA2alpha) is a rate-limiting enzyme involved in the regulation of prostaglandin E2 (PGE2) synthesis. KLF11 represses cPLA2alpha and down-regulates PGE2 synthesis.
Formal Description
Interaction-ID: 27191

gene/protein

KLF11

decreases_expression of

gene/protein

PLA2G4A

Drugbank entries Show/Hide entries for PLA2G4A
Comment The KLF11-mediated down-regulation of the cPLA2alpha-PGE2 pathway inhibits cell proliferation.
Formal Description
Interaction-ID: 27193

gene/protein

KLF11

decreases_activity of

via down-regulation of prostaglandin E2 biosynthesis
Comment KLF11-Thr-56 is phosphorylated by AKT upon EGFR activation.
Formal Description
Interaction-ID: 27195

gene/protein

AKT1

increases_phosphorylation of

gene/protein

KLF11

at Thr56 upon EGFR activation
Drugbank entries Show/Hide entries for AKT1
Comment KLF11 represses the cPLA2alpha promoter by recruiting the chromatin remodeling complex, Sin3a-HDAC.
Formal Description
Interaction-ID: 27199

gene/protein

KLF11

interacts (colocalizes) with

complex/PPI

SIN3A-HDAC complex

Comment KLF11 represses the cPLA2alpha promoter by recruiting the chromatin remodeling complex, Sin3a-HDAC.
Formal Description
Interaction-ID: 27200

complex/PPI

SIN3A-HDAC complex

increases_activity of

gene/protein

KLF11

Comment Mechanistically, KLF11 accomplishes this function by binding to the promoter via specific GC-rich sites and recruiting the Sin3-histone deacetylase chromatin remodeling complex. Further functional characterization reveals that this function of KLF11 can be reversed by epidermal growth factor receptor-AKT-mediated post-translational modification of threonine 56, a residue within its Sin3-binding domain.
Formal Description
Interaction-ID: 27202

gene/protein

AKT1

decreases_activity of

gene/protein

KLF11

via decreased SIN3A-HDAC recruitment
Drugbank entries Show/Hide entries for AKT1