General Information:

Id: 2,849
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
BTO:0000529 C6 glioma cell
article
Reference: Isakovic A et al.(2007) Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell. Mol. Life Sci. 64: 1290-1302 [PMID: 17447005]

Interaction Information:

Comment Metformin blocks proliferation of low-density glioma cells.
Formal Description
Interaction-ID: 26254

drug/chemical compound

Metformin

decreases_activity of

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Comment Metformin induces caspase-dependent apoptosis in confluent glioma cells.
Formal Description
Interaction-ID: 26255

drug/chemical compound

Metformin

increases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment Metformin-induced apoptosis is associated with mitochondrial depolarization and oxidative stress.
Formal Description
Interaction-ID: 26256

drug/chemical compound

Metformin

increases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment Metformin-induced apoptosis is associated with mitochondrial depolarization and oxidative stress.
Formal Description
Interaction-ID: 26257

drug/chemical compound

Metformin

increases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment Metformin caused c-Jun N-terminal kinase (JNK) activation.
Formal Description
Interaction-ID: 26258

drug/chemical compound

Metformin

increases_activity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for Metformin or MAPK8
Comment We have also observed that metformin treatment is associated with a drop in the pH value of culture medium, indicating an increase in glycolysis.
Formal Description
Interaction-ID: 26259

drug/chemical compound

Metformin

increases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment The antiglioma effect of metformin was reduced by compound C, an inhibitor of AMP-activated protein kinase (AMPK), and was mimicked by the AMPK agonist AICAR.
Formal Description
Interaction-ID: 26260

drug/chemical compound

Metformin

affects_activity of

complex/PPI

AMPK

Drugbank entries Show/Hide entries for Metformin