General Information:

Id: 2,847
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Ben Sahra I et al.(2008) The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27: 3576-3586 [PMID: 18212742]

Interaction Information:

Comment Metformin inhibits human prostate cancer cell growth.
Formal Description
Interaction-ID: 26234

drug/chemical compound

Metformin

decreases_activity of

disease

Prostate cancer

Drugbank entries Show/Hide entries for Metformin
Comment Metformin does not induce apoptosis.
Formal Description
Interaction-ID: 26235

drug/chemical compound

Metformin

NOT increases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment Metformin blocks the cell cycle in G0/G1.
Formal Description
Interaction-ID: 26236

drug/chemical compound

Metformin

decreases_activity of

process

cell cycle

Drugbank entries Show/Hide entries for Metformin
Comment The antiproliferative effect of metformin is not mediated by the AMPK-pathway.
Formal Description
Interaction-ID: 26237

drug/chemical compound

Metformin

decreases_activity of

not via AMPK signaling pathway
Drugbank entries Show/Hide entries for Metformin
Comment Metformin activated the AMP kinase (AMPK) pathway, a fuel sensor signaling pathway.
Formal Description
Interaction-ID: 26238

drug/chemical compound

Metformin

increases_activity of

process

AMPK signaling pathway

Drugbank entries Show/Hide entries for Metformin
Comment The cell cycle blockade was accompanied by a strong decrease of cyclin D1 protein level, retinoblastoma protein (pRb) phosphorylation and an increase in p27(kip) protein expression.
Formal Description
Interaction-ID: 26239

drug/chemical compound

Metformin

increases_expression of

gene/protein

CDKN1B

Drugbank entries Show/Hide entries for Metformin
Comment The cell cycle blockade was accompanied by a strong decrease of cyclin D1 protein level, retinoblastoma protein (pRb) phosphorylation and an increase in p27(kip) protein expression.
Formal Description
Interaction-ID: 26240

drug/chemical compound

Metformin

decreases_quantity of

gene/protein

CCND1

Drugbank entries Show/Hide entries for Metformin or CCND1
Comment The cell cycle blockade was accompanied by a strong decrease of cyclin D1 protein level, retinoblastoma protein (pRb) phosphorylation and an increase in p27(kip) protein expression.
Formal Description
Interaction-ID: 26241

drug/chemical compound

Metformin

decreases_phosphorylation of

gene/protein

RB1

Drugbank entries Show/Hide entries for Metformin or RB1