General Information:

Id: 2,760
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Japanese
article
Reference: Ohshige T et al.(2011) Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese PLoS ONE 6 [PMID: 22046406]

Interaction Information:

Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25539

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25540

increases_activity of

in Japanese, the risk allele is G
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25541

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25542

increases_activity of

in Japanese, the risk allele is C
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25543

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25545

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25546

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25547

increases_activity of

in Japanese, the risk allele is G
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25548

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25549

increases_activity of

in Japanese, the risk allele is G
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25550

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25552

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25554

NOT affects_activity of

in Japanese
Comment Type 2 diabetes risk loci identified through genome-wide association studies (GWAS) in European populations were examined in 3 independent Japanese samples. The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, and 3 SNPs, rs10830963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples.
Formal Description
Interaction-ID: 25556

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25558

affects_activity of

in Japanese, the risk allele is T
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25559

affects_activity of

in Japanese, the risk allele is G
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25560

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25561

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25562

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25563

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25564

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25565

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25566

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25567

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25568

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25569

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25570

NOT affects_activity of

in Japanese
Comment Of the 14 SNPs only MTNR1B rs1387153 and rs10830963 were associated with quantitative traits related to glucose metabolism.
Formal Description
Interaction-ID: 25571

NOT affects_activity of

in Japanese
Comment The risk allele of rs1531343 in the HMGA2 locus was significantly associated with increased FPG.
Formal Description
Interaction-ID: 25572

increases_activity of

phenotype

hyperglycemia

in blood plasma; after fasting, in Japanese, the risk allele is C