General Information:

Id: 2,580
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Florez JC et al.(2007) Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program Diabetes 56: 531-536 [PMID: 17259403]

Interaction Information:

Comment As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes. Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes. Results for ABCC8 A1369S were essentially identical to those for KCNJ11 E23K.
Formal Description
Interaction-ID: 24315

decreases_activity of

Comment As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes. Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes. Results for ABCC8 A1369S were essentially identical to those for KCNJ11 E23K.
Formal Description
Interaction-ID: 24316

increases_activity of

Comment As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes. Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes. Results for ABCC8 A1369S were essentially identical to those for KCNJ11 E23K.
Formal Description
Interaction-ID: 24317

decreases_activity of

drug/chemical compound

Metformin

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Comment As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes. Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes. Results for ABCC8 A1369S were essentially identical to those for KCNJ11 E23K.
Formal Description
Interaction-ID: 24318

decreases_activity of